Wild Derived Mouse Strains

Breeding Facility Studenec

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What are Wild Derived Strains?

The research of the house mouse, which is the most used mammal model, is the reason for 26 Nobel Prize awards. The biggest producer of the mouse strains is Jackson Laboratory in the USA, having more than 200 classical laboratory strains (CLS) in their portfolio. However, the genetic variability of the CLS is limited thanks to the low number of the founder lineage. On the other hand, the strains derived from mouse captured in the wild (WDS) have high genetic variability.

The breeding facility, located in Studenec is the detached workplace of the Institute of Vertebrate Biology AV CR. This breeding facility have the biggest collection of WDS in the world. This unique collection was created by combining a large collection of strains developed since 2008 by the Institute of Vertebrate Biology with the WDS collection held since 1976 by Francois Bonhomme in France. Currently, there are more than 70 strains derived from wild house mice (Mus musculus), but also strains derived from Mediterranean mice (Mus spretus) or Macedonian mice (Mus macedonicus).

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